A Rapid Subcortical Amygdala Route for Faces Irrespective of Spatial Frequency and Emotion.
Identifieur interne : 001309 ( Main/Exploration ); précédent : 001308; suivant : 001310A Rapid Subcortical Amygdala Route for Faces Irrespective of Spatial Frequency and Emotion.
Auteurs : Jessica Mcfadyen [Australie] ; Martial Mermillod [France] ; Jason B. Mattingley [Australie] ; Veronika Halász [Australie] ; Marta I. Garrido [Australie]Source :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 1529-2401 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Amygdale (système limbique) (physiologie), Expression faciale, Facteurs temps, Femelle, Humains, Jeune adulte, Magnétoencéphalographie (), Mâle, Reconnaissance visuelle des formes (physiologie), Stimulation lumineuse (), Traitement spatial (physiologie), Voies optiques (physiologie), Émotions (physiologie).
- MESH :
English descriptors
- KwdEn :
- Adolescent, Adult, Amygdala (physiology), Emotions (physiology), Facial Expression, Female, Humans, Magnetoencephalography (methods), Male, Pattern Recognition, Visual (physiology), Photic Stimulation (methods), Spatial Processing (physiology), Time Factors, Visual Pathways (physiology), Young Adult.
- MESH :
- methods : Magnetoencephalography, Photic Stimulation.
- physiology : Amygdala, Emotions, Pattern Recognition, Visual, Spatial Processing, Visual Pathways.
- Adolescent, Adult, Facial Expression, Female, Humans, Male, Time Factors, Young Adult.
Abstract
There is significant controversy over the existence and function of a direct subcortical visual pathway to the amygdala. It is thought that this pathway rapidly transmits low spatial frequency information to the amygdala independently of the cortex, and yet the directionality of this function has never been determined. We used magnetoencephalography to measure neural activity while human participants discriminated the gender of neutral and fearful faces filtered for low or high spatial frequencies. We applied dynamic causal modeling to demonstrate that the most likely underlying neural network consisted of a pulvinar-amygdala connection that was uninfluenced by spatial frequency or emotion, and a cortical-amygdala connection that conveyed high spatial frequencies. Crucially, data-driven neural simulations revealed a clear temporal advantage of the subcortical connection over the cortical connection in influencing amygdala activity. Thus, our findings support the existence of a rapid subcortical pathway that is nonselective in terms of the spatial frequency or emotional content of faces. We propose that that the "coarseness" of the subcortical route may be better reframed as "generalized."SIGNIFICANCE STATEMENT The human amygdala coordinates how we respond to biologically relevant stimuli, such as threat or reward. It has been postulated that the amygdala first receives visual input via a rapid subcortical route that conveys "coarse" information, namely, low spatial frequencies. For the first time, the present paper provides direction-specific evidence from computational modeling that the subcortical route plays a generalized role in visual processing by rapidly transmitting raw, unfiltered information directly to the amygdala. This calls into question a widely held assumption across human and animal research that fear responses are produced faster by low spatial frequencies. Our proposed mechanism suggests organisms quickly generate fear responses to a wide range of visual properties, heavily implicating future research on anxiety-prevention strategies.
DOI: 10.1523/JNEUROSCI.3525-16.2017
PubMed: 28283563
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000E60
- to stream PubMed, to step Curation: 000E57
- to stream PubMed, to step Checkpoint: 000E57
- to stream Ncbi, to step Merge: 004445
- to stream Ncbi, to step Curation: 004445
- to stream Ncbi, to step Checkpoint: 004445
- to stream Main, to step Merge: 001304
- to stream Main, to step Curation: 001309
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Rapid Subcortical Amygdala Route for Faces Irrespective of Spatial Frequency and Emotion.</title>
<author><name sortKey="Mcfadyen, Jessica" sort="Mcfadyen, Jessica" uniqKey="Mcfadyen J" first="Jessica" last="Mcfadyen">Jessica Mcfadyen</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia, j.mcfadyen@uq.edu.au.</nlm:affiliation>
<country wicri:rule="url">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia</wicri:regionArea>
<wicri:noRegion>Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mermillod, Martial" sort="Mermillod, Martial" uniqKey="Mermillod M" first="Martial" last="Mermillod">Martial Mermillod</name>
<affiliation wicri:level="4"><nlm:affiliation>Universite Grenoble Alpes, LPNC, F-38000 Grenoble, France and CNRS, LPNC, F-38000 Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Universite Grenoble Alpes, LPNC, F-38000 Grenoble, France and CNRS, LPNC, F-38000 Grenoble</wicri:regionArea>
<wicri:noRegion>38000 Grenoble</wicri:noRegion>
<orgName type="university">Université Grenoble-Alpes</orgName>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mattingley, Jason B" sort="Mattingley, Jason B" uniqKey="Mattingley J" first="Jason B" last="Mattingley">Jason B. Mattingley</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Halasz, Veronika" sort="Halasz, Veronika" uniqKey="Halasz V" first="Veronika" last="Halász">Veronika Halász</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garrido, Marta I" sort="Garrido, Marta I" uniqKey="Garrido M" first="Marta I" last="Garrido">Marta I. Garrido</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28283563</idno>
<idno type="pmid">28283563</idno>
<idno type="doi">10.1523/JNEUROSCI.3525-16.2017</idno>
<idno type="wicri:Area/PubMed/Corpus">000E60</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E60</idno>
<idno type="wicri:Area/PubMed/Curation">000E57</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E57</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000E57</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E57</idno>
<idno type="wicri:Area/Ncbi/Merge">004445</idno>
<idno type="wicri:Area/Ncbi/Curation">004445</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004445</idno>
<idno type="wicri:Area/Main/Merge">001304</idno>
<idno type="wicri:Area/Main/Curation">001309</idno>
<idno type="wicri:Area/Main/Exploration">001309</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">A Rapid Subcortical Amygdala Route for Faces Irrespective of Spatial Frequency and Emotion.</title>
<author><name sortKey="Mcfadyen, Jessica" sort="Mcfadyen, Jessica" uniqKey="Mcfadyen J" first="Jessica" last="Mcfadyen">Jessica Mcfadyen</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia, j.mcfadyen@uq.edu.au.</nlm:affiliation>
<country wicri:rule="url">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia</wicri:regionArea>
<wicri:noRegion>Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mermillod, Martial" sort="Mermillod, Martial" uniqKey="Mermillod M" first="Martial" last="Mermillod">Martial Mermillod</name>
<affiliation wicri:level="4"><nlm:affiliation>Universite Grenoble Alpes, LPNC, F-38000 Grenoble, France and CNRS, LPNC, F-38000 Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Universite Grenoble Alpes, LPNC, F-38000 Grenoble, France and CNRS, LPNC, F-38000 Grenoble</wicri:regionArea>
<wicri:noRegion>38000 Grenoble</wicri:noRegion>
<orgName type="university">Université Grenoble-Alpes</orgName>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mattingley, Jason B" sort="Mattingley, Jason B" uniqKey="Mattingley J" first="Jason B" last="Mattingley">Jason B. Mattingley</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Halasz, Veronika" sort="Halasz, Veronika" uniqKey="Halasz V" first="Veronika" last="Halász">Veronika Halász</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garrido, Marta I" sort="Garrido, Marta I" uniqKey="Garrido M" first="Marta I" last="Garrido">Marta I. Garrido</name>
<affiliation wicri:level="1"><nlm:affiliation>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title>
<idno type="eISSN">1529-2401</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Amygdala (physiology)</term>
<term>Emotions (physiology)</term>
<term>Facial Expression</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetoencephalography (methods)</term>
<term>Male</term>
<term>Pattern Recognition, Visual (physiology)</term>
<term>Photic Stimulation (methods)</term>
<term>Spatial Processing (physiology)</term>
<term>Time Factors</term>
<term>Visual Pathways (physiology)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Amygdale (système limbique) (physiologie)</term>
<term>Expression faciale</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Magnétoencéphalographie ()</term>
<term>Mâle</term>
<term>Reconnaissance visuelle des formes (physiologie)</term>
<term>Stimulation lumineuse ()</term>
<term>Traitement spatial (physiologie)</term>
<term>Voies optiques (physiologie)</term>
<term>Émotions (physiologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetoencephalography</term>
<term>Photic Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Amygdale (système limbique)</term>
<term>Reconnaissance visuelle des formes</term>
<term>Traitement spatial</term>
<term>Voies optiques</term>
<term>Émotions</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Amygdala</term>
<term>Emotions</term>
<term>Pattern Recognition, Visual</term>
<term>Spatial Processing</term>
<term>Visual Pathways</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Facial Expression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Time Factors</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Expression faciale</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Magnétoencéphalographie</term>
<term>Mâle</term>
<term>Stimulation lumineuse</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">There is significant controversy over the existence and function of a direct subcortical visual pathway to the amygdala. It is thought that this pathway rapidly transmits low spatial frequency information to the amygdala independently of the cortex, and yet the directionality of this function has never been determined. We used magnetoencephalography to measure neural activity while human participants discriminated the gender of neutral and fearful faces filtered for low or high spatial frequencies. We applied dynamic causal modeling to demonstrate that the most likely underlying neural network consisted of a pulvinar-amygdala connection that was uninfluenced by spatial frequency or emotion, and a cortical-amygdala connection that conveyed high spatial frequencies. Crucially, data-driven neural simulations revealed a clear temporal advantage of the subcortical connection over the cortical connection in influencing amygdala activity. Thus, our findings support the existence of a rapid subcortical pathway that is nonselective in terms of the spatial frequency or emotional content of faces. We propose that that the "coarseness" of the subcortical route may be better reframed as "generalized."SIGNIFICANCE STATEMENT The human amygdala coordinates how we respond to biologically relevant stimuli, such as threat or reward. It has been postulated that the amygdala first receives visual input via a rapid subcortical route that conveys "coarse" information, namely, low spatial frequencies. For the first time, the present paper provides direction-specific evidence from computational modeling that the subcortical route plays a generalized role in visual processing by rapidly transmitting raw, unfiltered information directly to the amygdala. This calls into question a widely held assumption across human and animal research that fear responses are produced faster by low spatial frequencies. Our proposed mechanism suggests organisms quickly generate fear responses to a wide range of visual properties, heavily implicating future research on anxiety-prevention strategies.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Grenoble</li>
</settlement>
<orgName><li>Université Grenoble-Alpes</li>
</orgName>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Mcfadyen, Jessica" sort="Mcfadyen, Jessica" uniqKey="Mcfadyen J" first="Jessica" last="Mcfadyen">Jessica Mcfadyen</name>
</noRegion>
<name sortKey="Garrido, Marta I" sort="Garrido, Marta I" uniqKey="Garrido M" first="Marta I" last="Garrido">Marta I. Garrido</name>
<name sortKey="Halasz, Veronika" sort="Halasz, Veronika" uniqKey="Halasz V" first="Veronika" last="Halász">Veronika Halász</name>
<name sortKey="Mattingley, Jason B" sort="Mattingley, Jason B" uniqKey="Mattingley J" first="Jason B" last="Mattingley">Jason B. Mattingley</name>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Mermillod, Martial" sort="Mermillod, Martial" uniqKey="Mermillod M" first="Martial" last="Mermillod">Martial Mermillod</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001309 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001309 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:28283563 |texte= A Rapid Subcortical Amygdala Route for Faces Irrespective of Spatial Frequency and Emotion. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28283563" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |